One person is dead and U.S. Highway 395 closed following a 3:37 p.m. crash at Milepost 223, six miles south of the city.
At least three people are also injured, according to the Washington State Patrol.
Other details have yet to be released.
A British Columbia man was killed this morning when his motorcycle was struck by a dumptruck at the intersection of Highways 20 and 395 about four miles northwest of the city.
Motorcyclist David P. Gilbride, 69, of New Westminster, B.C., was pronounced dead at the scene.
Washington State Patrol investigators and Colville Tribal Police are on-scene at a fatal crash just west of the Columbia River bridge northwest of the city.
An early morning crash Saturday on state Highway 395 claimed the life of a Connell man.
Manuel S. Valenzuela, 21, was pronounced dead at the scene at 4:43 a.m., the Washington State Patrol reported.
The crash occurred at Milepost 43, the patrol reported.
The name of a motorcyclist killed in a crash at 11:30 a.m. Tuesday is being withheld pending confirmation of identification and the results of an autopsy.
A Riverside man died at Mid Valley Hospital on Monday from injuries he sustained in a crash earlier in the day.
Eugene L. Layton, 87, died after being taken to the hospital, the Washington State Patrol reported.
An Omak woman was killed and her husband injured in a crash on state Highway 174.
The Washington State Patrol identified the deceased as Ramona J. Anderson, 80. She was pronounced dead at the scene at about 2:17 p.m. Monday.
A Mexican national was killed in a crash at 1:26 a.m. today on state Highway 28, five miles east of the city.
Angel L. Sandoval-Munoz, 24, of Tobasco, Mexico, was pronounced dead at the scene, the Washington State Patrol said.
A local man was killed and a Newman Lake woman injured in a three vehicle crash on state Highway 904.
Charles V. Mutschler, 63, of Cheney, was killed in the 7:28 p.m. Crash Sunday near the intersection of Fifth Street, the Washington State Patrol reported.